Rasburicaser DNA Origin

Product Description

Rasbelon Injection is used in thetreatment of high uric acid due to chemotherapy. It lowers uric acid levels in the blood which helps prevent kidney damage in cancer patients.

1. What is Rasburicase (rDNA origin)?

   • Rasburicase is a medication used to treat and prevent high levels of uric acid in the blood, a condition known as hyperuricemia. It is a recombinant urate oxidase enzyme derived from DNA technology.

2. How does Rasburicase work?

   • Rasburicase works by converting uric acid into a more soluble compound called allantoin, which can be easily excreted by the kidneys. This helps to reduce uric acid levels in the blood and prevent complications such as kidney stones and gout.

3. What conditions is Rasburicase used to treat?

   • Rasburicase is primarily used to manage hyperuricemia associated with tumor lysis syndrome (TLS), a condition that can occur as a result of cancer treatment when cancer cells break down rapidly and release large amounts of uric acid into the bloodstream.

4. How is Rasburicase administered?

   • Rasburicase is administered intravenously (IV) by a healthcare professional in a hospital or clinical setting. The dosage and duration of treatment will depend on the patient's medical condition and response to therapy.

5. What are the common side effects of Rasburicase?

   • Common side effects may include allergic reactions (such as rash, itching, swelling, or difficulty breathing), headache, nausea, vomiting, fever, and abdominal pain. These side effects are usually mild and transient.

6. Are there any serious side effects I should be aware of?

   • Yes, Rasburicase can cause serious side effects, including severe allergic reactions (anaphylaxis), hemolysis (destruction of red blood cells), methemoglobinemia (a condition where the blood contains elevated levels of methemoglobin), and severe hypersensitivity reactions. Seek immediate medical attention if you experience any severe or persistent side effects.

7. Who should not receive Rasburicase?

   • Rasburicase should not be used in patients with a known allergy to rasburicase or any of the ingredients in the medication. It should also be used with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as it may increase the risk of hemolysis.

8. Can Rasburicase interact with other medications?

   • Rasburicase may interact with certain medications, including other chemotherapy drugs and medications that affect kidney function. Inform your healthcare provider about all medications, supplements, and herbal remedies you are taking before starting Rasburicase treatment.

9. How should Rasburicase be stored?

   • It should be stored at room temperature (20-25C) away from light and moisture. Follow the specific storage instructions provided by your pharmacist.
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Efficient Uric Acid Reduction for Chemotherapy Patients

Rasburicase offers rapid and reliable control of elevated uric acid levels in both pediatric and adult patients dealing with hematologic malignancies or solid tumors. Its prompt action significantly minimizes the risk of renal complications associated with tumor lysis syndrome during chemotherapy. High purity and robust uricase enzymatic activity, with more than 1.0 Units/mg protein, ensure strong clinical efficacy.


Advanced Biotechnology and Purity Standards

Produced using recombinant DNA technology in yeast culture at 2830C, Rasburicase is free from animal-derived proteins and preservatives. It is formulated as a lyophilized powder and complies with all relevant pharmacopeial standards, ensuring a safe and consistent product experience for healthcare providers and patients.


Safe Handling and Administration Guidelines

Each vial must be reconstituted with sterile water for injection only, then diluted in 0.9% sodium chloride. Rasburicase should never be mixed with dextrose-containing solutions, as incompatibility may occur. The reconstituted solution is stable for 24 hours at 28C, though administration immediately after preparation is recommended for optimal efficacy.